Structural, Biochemical, and Computational Characterization of the Glycoside Hydrolase Family 7 Cellobiohydrolase of the Tree-Killing Fungus Heterobasidion Irregulare

Majid Haddad Momeni; Christina M. Payne; Henrik Hansson; Nils Egil Mikkelsen; Jesper Svedberg; Ake Engström; Mats Sandgren; Gregg T. Beckham; Jerry Stahlberg

doi:10.1074/jbc.M112.440891

Structural, Biochemical, and Computational Characterization of the Glycoside Hydrolase Family 7 Cellobiohydrolase of the Tree-Killing Fungus Heterobasidion Irregulare

Majid Haddad Momeni
, Christina M. Payne
, Henrik Hansson
, Nils Egil Mikkelsen
, Jesper Svedberg
, Ake Engström
, Mats Sandgren
, Gregg T. Beckham
, Jerry Stahlberg

BioEconomy and Sustainable Transportation

Swedish University of Agricultural Sciences
National Renewable Energy Laboratory
University of Kentucky
Uppsala University

Research output: Contribution to journal › Article › peer-review

66 Scopus Citations

Abstract

Background: Family 7 cellulases exhibit significant hydrolytic potential in cellulose degradation. Results: Wereport the Heterobasidion irregulare GH7 structure and compare it with other GH7 cellobiohydrolases with simulation. Conclusion: H. irregulare Cel7A exhibits intermediate dynamical and structural properties between Phanerochaete chrysosporium Cel7D and Hypocrea jecorina Cel7A. Significance: These results highlight regions of family 7 cellobiohydrolases important for carbohydrate processivity and association- dissociation rates on cellulose.

Original language	American English
Pages (from-to)	5861-5872
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M112.440891 https://doi.org/10.1074/jbc.M112.440891
State	Published - 22 Feb 2013

NLR Publication Number

NREL/JA-5100-57632

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Momeni, M. H., Payne, C. M., Hansson, H., Mikkelsen, N. E., Svedberg, J., Engström, A., Sandgren, M., Beckham, G. T., & Stahlberg, J. (2013). Structural, Biochemical, and Computational Characterization of the Glycoside Hydrolase Family 7 Cellobiohydrolase of the Tree-Killing Fungus Heterobasidion Irregulare. Journal of Biological Chemistry, 288(8), 5861-5872. https://doi.org/10.1074/jbc.M112.440891, https://doi.org/10.1074/jbc.M112.440891

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title = "Structural, Biochemical, and Computational Characterization of the Glycoside Hydrolase Family 7 Cellobiohydrolase of the Tree-Killing Fungus Heterobasidion Irregulare",

abstract = "Background: Family 7 cellulases exhibit significant hydrolytic potential in cellulose degradation. Results: Wereport the Heterobasidion irregulare GH7 structure and compare it with other GH7 cellobiohydrolases with simulation. Conclusion: H. irregulare Cel7A exhibits intermediate dynamical and structural properties between Phanerochaete chrysosporium Cel7D and Hypocrea jecorina Cel7A. Significance: These results highlight regions of family 7 cellobiohydrolases important for carbohydrate processivity and association- dissociation rates on cellulose.",

author = "Momeni, \{Majid Haddad\} and Payne, \{Christina M.\} and Henrik Hansson and Mikkelsen, \{Nils Egil\} and Jesper Svedberg and Ake Engstr{\"o}m and Mats Sandgren and Beckham, \{Gregg T.\} and Jerry Stahlberg",

year = "2013",

month = feb,

day = "22",

doi = "10.1074/jbc.M112.440891",

language = "American English",

volume = "288",

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Momeni, MH, Payne, CM, Hansson, H, Mikkelsen, NE, Svedberg, J, Engström, A, Sandgren, M, Beckham, GT & Stahlberg, J 2013, 'Structural, Biochemical, and Computational Characterization of the Glycoside Hydrolase Family 7 Cellobiohydrolase of the Tree-Killing Fungus Heterobasidion Irregulare', Journal of Biological Chemistry, vol. 288, no. 8, pp. 5861-5872. https://doi.org/10.1074/jbc.M112.440891, https://doi.org/10.1074/jbc.M112.440891

Structural, Biochemical, and Computational Characterization of the Glycoside Hydrolase Family 7 Cellobiohydrolase of the Tree-Killing Fungus Heterobasidion Irregulare. / Momeni, Majid Haddad; Payne, Christina M.; Hansson, Henrik et al.
In: Journal of Biological Chemistry, Vol. 288, No. 8, 22.02.2013, p. 5861-5872.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Structural, Biochemical, and Computational Characterization of the Glycoside Hydrolase Family 7 Cellobiohydrolase of the Tree-Killing Fungus Heterobasidion Irregulare

AU - Momeni, Majid Haddad

AU - Payne, Christina M.

AU - Hansson, Henrik

AU - Mikkelsen, Nils Egil

AU - Svedberg, Jesper

AU - Engström, Ake

AU - Sandgren, Mats

AU - Beckham, Gregg T.

AU - Stahlberg, Jerry

PY - 2013/2/22

Y1 - 2013/2/22

N2 - Background: Family 7 cellulases exhibit significant hydrolytic potential in cellulose degradation. Results: Wereport the Heterobasidion irregulare GH7 structure and compare it with other GH7 cellobiohydrolases with simulation. Conclusion: H. irregulare Cel7A exhibits intermediate dynamical and structural properties between Phanerochaete chrysosporium Cel7D and Hypocrea jecorina Cel7A. Significance: These results highlight regions of family 7 cellobiohydrolases important for carbohydrate processivity and association- dissociation rates on cellulose.

AB - Background: Family 7 cellulases exhibit significant hydrolytic potential in cellulose degradation. Results: Wereport the Heterobasidion irregulare GH7 structure and compare it with other GH7 cellobiohydrolases with simulation. Conclusion: H. irregulare Cel7A exhibits intermediate dynamical and structural properties between Phanerochaete chrysosporium Cel7D and Hypocrea jecorina Cel7A. Significance: These results highlight regions of family 7 cellobiohydrolases important for carbohydrate processivity and association- dissociation rates on cellulose.

UR - https://www.scopus.com/pages/publications/84874318103

U2 - 10.1074/jbc.M112.440891

DO - 10.1074/jbc.M112.440891

M3 - Article

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AN - SCOPUS:84874318103

SN - 0021-9258

VL - 288

SP - 5861

EP - 5872

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 8

ER -

Structural, Biochemical, and Computational Characterization of the Glycoside Hydrolase Family 7 Cellobiohydrolase of the Tree-Killing Fungus Heterobasidion Irregulare

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