Engineered Microorganisms for the Production of Intermediates and Final Products

Christopher Johnson; Peter St. John; Gregg Beckham; Joshua Elmore; Adam Guss; Davinia Salvachua Rodriguez; Gayle Bentley; George Peabody V; Taraka Dale; Ramesh Jha; Niju Narayanan

Engineered Microorganisms for the Production of Intermediates and Final Products

Christopher Johnson (Inventor)
, Peter St. John (Inventor)
, Gregg Beckham (Inventor)
, Joshua Elmore (Inventor)
, Adam Guss (Inventor)
, Davinia Salvachua Rodriguez (Inventor)
, Gayle Bentley (Inventor)
, George Peabody V (Inventor)
, Taraka Dale (Inventor)
, Ramesh Jha (Inventor)
, Niju Narayanan (Inventor)

National Renewable Energy Laboratory
Pacific Northwest National Laboratory
Oak Ridge National Laboratory
Los Alamos National Laboratory

Research output: Patent

Abstract

The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.

Original language	American English
Patent number	11,518,975 B2
Filing date	6/12/22
State	Published - 2022

NLR Publication Number

NREL/PT-2800-84758

Keywords

endogenous genetic deletion
glucose dehydrogenase
phosphoenolpyruvate carboxylase
pyruvate kinase

Access to Document

https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/11518975

Cite this

Johnson, C., St. John, P., Beckham, G., Elmore, J., Guss, A., Salvachua Rodriguez, D., Bentley, G., Peabody V, G., Dale, T., Jha, R., & Narayanan, N. (2022). Engineered Microorganisms for the Production of Intermediates and Final Products. (Patent No. 11,518,975 B2). National Laboratory of the Rockies (NLR). https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/11518975

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title = "Engineered Microorganisms for the Production of Intermediates and Final Products",

abstract = "The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.",

keywords = "endogenous genetic deletion, glucose dehydrogenase, phosphoenolpyruvate carboxylase, pyruvate kinase",

author = "Christopher Johnson and \{St. John\}, Peter and Gregg Beckham and Joshua Elmore and Adam Guss and \{Salvachua Rodriguez\}, Davinia and Gayle Bentley and \{Peabody V\}, George and Taraka Dale and Ramesh Jha and Niju Narayanan",

year = "2022",

language = "American English",

publisher = "National Laboratory of the Rockies (NLR)",

address = "United States",

type = "Patent",

note = "11,518,975 B2",

}

TY - PAT

T1 - Engineered Microorganisms for the Production of Intermediates and Final Products

AU - Johnson, Christopher

AU - St. John, Peter

AU - Beckham, Gregg

AU - Elmore, Joshua

AU - Guss, Adam

AU - Salvachua Rodriguez, Davinia

AU - Bentley, Gayle

AU - Peabody V, George

AU - Dale, Taraka

AU - Jha, Ramesh

AU - Narayanan, Niju

PY - 2022

Y1 - 2022

N2 - The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.

AB - The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.

KW - endogenous genetic deletion

KW - glucose dehydrogenase

KW - phosphoenolpyruvate carboxylase

KW - pyruvate kinase

M3 - Patent

M1 - 11,518,975 B2

Y2 - 2022/12/06

PB - National Laboratory of the Rockies (NLR)

ER -

Engineered Microorganisms for the Production of Intermediates and Final Products

Abstract

NLR Publication Number

Keywords

Access to Document

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