Overview
Research Interests
Development of thermophilic bacteria for improved biomass deconstruction
Biomass degrading mechanisms of thermophilic bacteria
Metabolic modeling and pathway engineering in microbes for upgrading sugar to fuels and high value chemicals
Metabolic enzyme characterization, modeling, and engineering (thermostability, cofactor specificity, binding, rate limiting step)
Characterization, modeling, and engineering of biomass degrading enzymes from mesophilic and thermophilic bacteria
Quantum chemical calculations for the study of thermochemical properties and processes
Molecular dynamics
Quantum chemistry
Computational modeling
Computer software development (for applications in molecular dynamics [MD] and quantum mechanics [QM] calculations)
Protein purification
Protein characterization
Metabolic modeling
Professional Experience
Research Associate, Scripps Research Institute, Department of Molecular Biology, 2006–2008
Graduate Research Assistant, University of Texas, Department of Chemistry and Biochemistry, 2001–2006
Visiting Research Fellow, Universitt Mainz, Germany, Institut für Physikalische Chemie, 2004 and 2005
IMCC exchange fellow, Université de Lille I/ University of Texas, Austin, 2001
Education/Academic Qualification
Mathématiques Speciales, Lycée Faidherbe
Mathématiques Superieures, Lycée Faidherbe
PhD, Chemical Physics, University of Texas
Bachelor, Physics (with honors), minors in Mathematics and Chemistry, Université de Lille
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Collaborations and Top Research Areas From the Past 5 Years
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Biochemical Characterization of Xyloglucan Galactosyltransferases MUR3 and XLT2 from Spirodela polyrhiza: Article No. e70754
Corulli, C., Graf, A., Chapla, D., Zhang, L., Ziegler, S., Byrnes, J., Bomble, Y., Moremen, K., Urbanowicz, B. & Prabhakar, P., 2026, In: Plant Journal. 125, 5, 15 p.Research output: Contribution to journal › Article › peer-review
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Building an Expanded Bio-Based Economy Through Synthetic Biology: Article No. 108775
Garza Elizondo, A., del Valle Kessra, I., Prates, E., Komp, E., Phillips, E., Ashok, N., Jacobson, D., Webb, E., Bomble, Y., Alexander, W., Tannous, J., Tsai, C.-J., Parrott, W., Yang, X., Urbanowicz, B., Bartley, L., Maranas, C., Tuskan, G., Guss, A. & Eckert, C., 2026, In: Biotechnology Advances. 87, 30 p.Research output: Contribution to journal › Article › peer-review
2 Scopus Citations -
Deconstruction by C. Thermocellum-From Microbe Mediated to Dynamic Redistribution of Cellulosomes
Yarbrough, J., Hengge, N., Xu, Q., Ziegler, S., Chung, D., Huang, S., Morais, S., Mizrahi, I., Bayer, E. & Bomble, Y., 2026, In: Life Science Alliance. 9, 3, 16 p.Research output: Contribution to journal › Article › peer-review
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Engineering Clostridium thermocellum for Production of 2,3-Butanediol from Cellulose: Article No. e00269
Jilani, S. B., Ashok, N., Bomble, Y., Guss, A. & Olson, D., 2026, In: Metabolic Engineering Communications. 22, 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus Citations -
PET-FBA: A Lightweight Enzyme Allocation and Thermodynamics-Constrained Flux Analysis Approach to Explore Escherichia Coli Metabolic Adaptation to Intracellular Acidification
Wu, C., Law, J., Onyenemezu, O., Roy, J., St. John, P., Jernigan, R., Bomble, Y. & Jarboe, L., 2026, In: Metabolic Engineering. 94, p. 202-212 11 p.Research output: Contribution to journal › Article › peer-review
Awards and Honors
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NREL Distinguished Member of Research Staff
Zhu, K. (Recipient), Vidal, J. (Recipient), Tao, L. (Recipient), Tan, J. (Recipient), Smith, W. (Recipient), Schaidle, J. (Recipient), Reese, M. (Recipient), Parilla, P. (Recipient), Palmintier, B. (Recipient), Musial, W. (Recipient), Moriarty, P. (Recipient), Mann, M. (Recipient), Mai, T. (Recipient), Luther, J. (Recipient), Laurens, L. (Recipient), King, J. (Recipient), Johnston, S. (Recipient), Jackson, R. (Recipient), Hodge, B.-M. (Recipient), Heath, G. (Recipient), Hale, E. (Recipient), Habas, S. (Recipient), Gruchalla, K. (Recipient), Gevorgian, V. (Recipient), Geisz, J. (Recipient), Fleming, P. (Recipient), Farrell, J. (Recipient), Ding, F. (Recipient), Denholm, P. (Recipient), Ciesielski, P. (Recipient), Churchfield, M. (Recipient), Bomble, Y. (Recipient), Blackburn, J. (Recipient) & Ciesielski, P. (Recipient), 2021
Prize: Honorary award