Overview
Research Interests
Protein engineering and biophysics in microbial systems, including:
Development of high-throughput platforms for protein design and characterization
Computational protein design and bioinformatics for synthetic biology applications
Design of novel microorganisms for optimized production of high-value products.
Protein engineering and design
Synthetic biology
Molecular microbiology
Education/Academic Qualification
Bachelor, Chemical Engineering, Montana State University
PhD, Bioengineering, University of Washington
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Collaborations and Top Research Areas From the Past 5 Years
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Coupling Waste Feedstocks to Microbial Protein Production in a Circular Food System
Uekert, T., Bleem, A., Holmes, E., Pal, A., Johnson, C. & Beckham, G., 2025, In: ACS Sustainable Chemistry and Engineering. 13, 2, p. 709-724 16 p.Research output: Contribution to journal › Article › peer-review
10 Scopus Citations -
Insights Into Genetic Determinants of Volatile Fatty Acid Catabolism in Cupriavidus necator H16
Holmes, E., Breunig, S., Johnson, C., Beckham, G. & Bleem, A., 2025, In: Applied and Environmental Microbiology. 91, 7, 17 p.Research output: Contribution to journal › Article › peer-review
1 Scopus Citations -
Metabolic Modification of Sphingobium lignivorans SYK-6 for Lignin Valorization Through the Discovery of an Unusual Transcriptional Repressor of Lignin-Derived Dimer Catabolism
Kato, R., Kuatsjah, E., Fujita, M., Bleem, A., Hishiyama, S., Katahira, R., Senda, T., Beckham, G., Kamimura, N. & Masai, E., 2025, In: Green Chemistry. 27, 5, p. 1540-1555 16 p.Research output: Contribution to journal › Article › peer-review
8 Scopus Citations -
Adaptive Laboratory Evolution and Metabolic Engineering of Cupriavidus necator for Improved Catabolism of Volatile Fatty Acids
Holmes, E., Bleem, A., Johnson, C. & Beckham, G., 2024, In: Metabolic Engineering. 86, p. 262-273 12 p.Research output: Contribution to journal › Article › peer-review
6 Scopus Citations -
Catalytic Carbon-Carbon Bond Cleavage in Lignin via Manganese-Zirconium-Mediated Autoxidation: Article No. 862
Palumbo, C., Gu, N., Bleem, A., Sullivan, K., Katahira, R., Stanley, L., Kenny, J., Ingraham, M., Ramirez, K., Haugen, S., Amendola, C., Stahl, S. & Beckham, G., 2024, In: Nature Communications. 15, 12 p.Research output: Contribution to journal › Article › peer-review
44 Scopus Citations